What is Cetrorelix?

Cetrorelix is Generic Name of CETROTIDE, a prescription medication used to relieve the effects of infertility. Cetrorelix can be used with or without other medicines.

Cetrorelix belongs from a class of medicines called Gonadotropin Releasing Hormone Antagonists.

Cetrorelix is used in women for some fertility treatments (controlled ovarian stimulation). This medicine works by preventing eggs from being released too early (premature ovulation) by blocking the hormone (gonadotropin-releasing hormone-GnRH) which allows eggs to be released from the ovaries. This gives the eggs time to grow properly. This drug is usually combined with another hormone (human chorionic gonadotropin-hCG) to help you get pregnant.HCG is used to induce the development and release of a mature egg (ovulation). This drug must not be used if you are pregnant. Before your first dose, your doctor can order a pregnancy test.

Cetrorelix Uses

Cetrorelix is used in women for some fertility treatments (controlled ovarian stimulation). This medicine works by preventing eggs from being released too early allowing eggs to be released from the ovaries. This gives the eggs time to grow properly. This drug is usually combined with another hormone (human chorionic gonadotropin-hCG) to help you get pregnant.

How to use Cetrorelix kit?

  • Read the Patient Information Leaflet, if available from your pharmacist, before you start using cetrorelix and any time you refill.clear all queries from your doctor or pharmacist.
  • Learn all the guidance for planning and use from your health care provider and the product kit. Follow the instructions to apply the liquid to the drug. Shake the vial gently to blend. Using the liquid directly after mixing.
  • Check this product if any discoloration is there or not before use.
  • Inject this medicine under the skin as instructed by your doctor, usually a few days a day. It should be injected into the stomach section, at least one inch away from the belly button.
  • Carefully follow the doctor's directions on when to start and end the drug.
  • Before each dose is injected, clean the injection site with alcohol. Change the injection site each time to reduce the damage to the skin.
  • Use this drug exactly as instructed by your doctor to make the most of it. Do not raise your dosage or use this medication more frequently or longer than necessary.
  • Learn proper storage and disposal processes of medical supplies.

Cetrorelix Side Effects

Some of the common side effects of Cetrorelix are:

  • Nausea
  • Headache
  • Pain / Bruising / Redness / Swelling / Swelling at the injection site can occur.

Many people who use this drug do not have significant side effects.

This medicine can cause a condition known as ovarian hyperstimulation syndrome (OHSS). These issues can occur during or after treatment. Seldom, intense OHSS causes fluid to build up suddenly in the stomach, chest, and heart.

Get medical attention right away if you experience the following side effects:

  • Extreme pain
  • Swelling in the lower abdominal (pelvic) region
  • Nausea
  • Vomiting
  • Sudden / fast weight gain
  • Decreased urination
  • Rashes
  • Itching
  • Difficulty in breathing
  • Dizziness
  • Headache
  • Redness


Before using cetrorelix, inform your doctor or pharmacist whether you are allergic to it or to other gonadotropin-releasing hormone (GnRH) products; or if you have any other allergies. This product can contain inactive ingredients that may cause allergic reactions or other problems. Please talk to your health care advisor for more information.

Before taking this drug, tell your doctor or pharmacist your medical history, especially the following: history of serious allergic reactions, kidney disease.

Tell your doctor of all the things you need when you have surgery (such as prescription drugs, nonprescription drugs, and herbal products).

Avoid taking this drug if you are pregnant. This drug must not be taken while you are pregnant. If you think you are pregnant, ask your doctor about risk and benefits.

It is not clear whether this medication is transferred into breast milk. Owing to the potential risk to the child, breast-feeding is not recommended during use of this drug. Please consult your doctor.

Serious interactions

Drug interactions can cause reactions and change the way your drugs work or increase your risk of serious side effects. Keep a check on all the medications you use including prescribed and non prescribed drugs and any herbal products) and share them with your doctor and pharmacist. Do not start, stop or change the dosage of any drug without your doctor's permission.


When someone has overdosed and has extreme signs such as passing out or respiratory problems

  • Do not share with anyone this drug.Do not share with anyone this drug.
  • Laboratory and/or diagnostic tests (such as cervical ultrasound, hormone levels) can be performed when you are using this drug. Keep all medical and laboratory appointments in place. For more info, contact your doctor.

Missed Dose

It is very important to follow the schedule. In case you miss any dose consult an expert.


Different products have different storage requirements. Please refer to the storage details printed on your package for the exact temperature range

Do not flush the medication in toilets, washrooms or drains.

For Adult: Dosage Forms & Strengths

Injectable solution

  • 0.25mg
  • 3mg

Infertility treatment

Single-dose regimen should be 3 mg SC, serum estradiol levels show appropriate stimulation response which is day 7; if hCG not administered within 4 days, continue dose at 0.25 mg/day until hCG administered

Multiple-dose regimen

  • 0.25 mg SC two times a day, morning or evening of stimulation day 5 or morning of stimulation day 6; continue until hCG administered
  • For Pediatric use, it is not recommended

Mechanism for action

Cetrorelix binds to the hormone receptor-releasing gonadotropin and functions as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to pituitary cell membrane receptors and thus regulates the release of LH and FSH in a dose-dependent manner.

  Cetrorelix schedule Cetrorelix schedule
Multiple dose n = 635 Single dose n = 187 Multiple dose n = 86 Single dose n = 39
Genitourinary Ovarian disorder 28 4 7 3
Neurological headache 8 0 7 1
Gastrointestinal nausea 8 2 1 0


The LHRH antagonist Cetrorelix https://www.sciencedirect.com/science/article/abs/pii/S0015028297814070
The GnRH antagonist cetrorelix reduces cyclophosphamide hhttps://academic.oup.com/humrep/article/19/6/1294/2356597

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Frequently Asked Questions

What are the uses of Cetrorelix?

Cetrorelix is used in women for some fertility treatments (controlled ovarian stimulation). This medicine works by preventing eggs from being released too early (premature ovulation) by blocking the hormones (gonadotropin-releasing hormone-GnRH) that allows eggs to be released from the ovaries. This leads the growth time of eggs to increase properly. This drug is usually combined with another hormone (human chorionic gonadotropin-hCG) to help you get pregnant.

What are the side effects of Cetrorelix?

Extreme pain, Swelling in the lower abdominal (pelvic) region, Nausea, Vomiting, Sudden/fast weight gain, Decreased urination, Rashes, Itching, Difficulty in breathing, Dizziness, Headache, Redness.

What is the role of Cetrorelix in IVF?

Cetrorelix avoids premature LH surge that occurred elsewhere in the CC-FSH-cetrorelix protocol.basically it is used for IVF treatment.

What happens if you take cetrotide late?

Cetrotide 0.25 mg should be administered at 24 hours intervals of time. But if you forget to take Cetrotide 0.25 mg at the same time it will lead to no big problem to administer this dose at a different time of the same day.

What should be avoided while taking cetrorelix

Follow your doctor's orders for any limits on food, drinks, or operation.

What all drugs will Influence CETRORELIX (CETROTIDE)?

Many other drugs and medicine can interact with cetrorelix, including prescription and over-the-counter medicines, vitamins and some herbal products. Tell each of your health care professionals about all the medications you are taking now and any medicines you start or stop using.

How fast is Cetrotide working?

In women, Cetrotide delays LH-surgery and, subsequently, ovulation in a dose-dependent manner. FSH levels shall not be affected at doses used during managed ovarian stimulation. After a single 3 mg dose of Cetrotide®, a period of action of at least 4 days has been identified.

Will Cetrorelix be used to treat PCOS?

Researchers have experimented with PCOS on a drug named cetrorelix in mice. The drug blocks gonadotropic hormones, which restrict ovulation, and thus also lowers AMH levels. They found that cetrorelix mice stopped having symptoms of PCOS.
But Cetrorelix may not be the cure that women suffering from PCOS are looking for. For one thing, it's not the solution for PCOS sufferers who are trying to conceive because it effectively shuts down a woman's cycle. Some treatments—including medications such as letrozole or follicle-stimulating hormones—work reasonably well with 60 percent of women being pregnant after using them.
Although cetrorelix may alleviate other symptoms of PCOS, it may be too powerful for a medication to be a reasonable remedy. Cetrorelix needs to be injected regularly.
It makes sense that if you shut down the menstrual centers with cetrorelix, the symptoms of PCOS are decreased, but there are other ways to suppress the menstrual cycle that we have used for many years to treat PCOS.
Weight loss is another method that is widely prescribed. If you have PCOS, speak to your doctor about the best care options for you.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.