Allopurinol

By Medicover Hospitals / 08 Mar 2021
Home | Medicine | Allopurinol

What is Allopurinol?

Allopurinol is a drug that is used to lower elevated blood uric acid levels. It is marketed under the brand names Zyloprim and others. It is used to avoid gout, certain forms of kidney stones, and elevated uric acid levels that may occur as a result of chemotherapy. It's either taken orally or inserted into a vein.

1. Allopurinol Uses
2. Allopurinol Side effects
3. Precautions
4. Overdose
5. Storage
6. Allopurinol vs Colchicine
7. Frequently Asked Questions
8. Citations

Allopurinol Uses:

Allopurinol is used for the treatment of gout and certain types of kidney stones. It is also used to prevent increased levels of uric acid in patients receiving chemotherapy for cancer. These patients may have increased levels of uric acid due to the release of uric acid from dying cancer cells. Allopurinol works by reducing the amount of uric acid produced by the body. Increased levels of uric acid may cause problems with the gut and kidneys.

How to use Allopurinol

• This drug should be taken orally once a day or as instructed by your doctor. To relieve stomach upset, take this medicine after a meal. If your everyday dosage is more than 300 milligrams, you will need to take several smaller doses during the day (consult your doctor for directions).
• Drink a full glass of water for each dose and at least 8 additional glasses (8 ounces each) of fluid during the day. Consult your doctor for further instructions if your doctor has advised you to drink less fluid for any medical purposes. Your doctor can also advise you on how to reduce acid in your urine (for example, by preventing high doses of ascorbic acid/vitamin C).
• Dosage is determined by your medical condition and treatment reaction. To get the most advantages and benefits from this drug, take it every day. Take it at the same time every day to help you recall.
• It may take several weeks for this drug to take effect in the treatment of gout. For several months after starting this drug, you may experience further gout attacks as your body loses excess uric acid. Allopurinol isn't an analgesic. Continue to take your prescribed gout medications (e.g., colchicine, ibuprofen, indomethacin) as instructed by your doctor to relieve gout pain.

Allopurinol Side Effects:

• Rash
• Nausea
• Renal failure
• Vomiting
• Joint pain
• Blood disorders
• Difficulty breathing
• Cardiovascular abnormalities
• Cataracts
• Confusion
• Dizziness
• Bruise
• Nosebleed
• Foot drop
• Blood in the urine
• Liver damage
• Decreased muscle tone
• Inflammation of the iris in the eye
• Kidney function abnormality
• Severe vision impairment
• Inflammation of the nerves
• Sore throat
• Itching

Precautions:

• If you are allergic to allopurinol, or if you have had a bad reaction to it, or if you have any other reactions, alert your doctor or pharmacist before taking it. Inactive ingredients can be present in this product, causing allergic reactions or other issues.
• Tell your doctor or pharmacist about any medical conditions you have, particularly if you have: liver disease, kidney disease, diabetes, high blood pressure (hypertension), or irregular diets (e.g., fasting).
• This medication has the potential to make you drowsy. You can become drowsy if you consume alcohol. Do not drive, operate machinery, or engage in any other activity that requires alertness until you are sure you can do so safely. This drug's efficacy can be harmed by alcohol. Alcohol consumption should be restricted.
• Kidney function deteriorates as you age. The kidneys eliminate this drug. As a result, older adults may be more susceptible to side effects while taking this medication.
• This drug should only be taken during pregnancy when it is required urgently. Consult your doctor.
• Breast milk contains allopurinol. Before you start breastfeeding, talk to your doctor.

Interactions:

Drug interactions can cause your drugs to function differently or put you at risk for severe side effects. Keep a list of all the medicines you use (including prescription and over-the-counter medications, as well as herbal remedies) and share it with your doctor and pharmacist. Without your doctor's permission, do not begin, stop, or alter the dosage of any medications.

Blood thinners (warfarin), capecitabine, and didanosine are some of the products that may interfere with this drug.

Overdose:

If you or someone has taken too much of this medicine and has serious symptoms such as passing out or trouble breathing, seek emergency medical help. Symptoms of overdose can include severe drowsiness, fainting, seizures, fast heartbeat.

Note:

• Do not share this medication with anyone else even if they have the same symptoms
• Lab and medical tests such as blood pressure, liver function should be done while you are taking this medication. Consult your doctor for more details and information.

Missed Dose:

If you forgot to take any dose, take it as soon as you recall it. But if it is near the time of the next dose, skip the forgotten dose. Take your next dosage at regular intervals of time. Do not double the dose.

Storage:

• Store at room temperature far away from direct sunlight, heat, and moisture. Do not store in the bathroom as well. Keep all medications away from small kids.
• Never flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it gets expired or no longer in use. Consult your pharmacist or local waste disposal company.

Allopurinol vs Colchicine:

Allopurinol	Colchicine
Also known Zyloprim	Also known Colcrys
Lowers uric acid levels in the blood, and prevents gout flare-ups.	Prevents and treats gout.
Used for treating Gout, High uric acid in cancer, Recurrent kidney stones	Used for - Gout, Gout prevention, Familial Mediterranean fever, Behcet's disease, and Inflammation of the heart.
Dosage forms- Injection, Pill	Dosage forms - Pill
Kidney stones can be formed while taking allopurinol, so you need to drink a lot of fluids to help prevent this.	Doses need to be changed if you have kidney or liver problems.