The majority of the LMCA disease patients are symptomatic because occlusion of this vessel compromises approximately 75% of the blood flow to the left ventricle (LV). Patients are at a higher risk of major cardiovascular events unless protected by a collateral flow (It is an important alternative source of blood supply when the original vessels fail to provide sufficient blood). Generally, LMCA disease is diagnosed through coronary angiography.
Although LMCA disease is not clearly distinguished from other forms of coronary artery disease by the use of noninvasive imaging tests, certain findings on exercise tests or the electrocardiogram (ECG, in patients with acute coronary syndromes) may reveal LMCA disease. These involve diffuse and extreme ST-segment variance on ECG leading to critical ECG monitoring or hypotension and ventricular arrhythmias through the exercise tests.
Coronary angiography remains the gold standard diagnostic technique for the diagnosis of clinically significant LMCA disease.
Coronary Vasodilatory Reserve (CVR) represents the ratio of hyperaemic to basal flow through the epicardial artery and the corresponding myocardial bed and reflects flow resistance. The importance is influenced by coronary microcirculation and haemodynamic conditions, unlike FFR. While used in the further evaluation of angiographically indeterminate lesions, no clear studies have discussed the use of this diagnostic adjunct in LMCA disease assessment.
To minimize the risk of future cardiovascular problems, all patients with LMCA disease should undergo preventive therapies. Preventive treatments include avoidance of smoking, exercise, lipid-lowering statin treatment, diabetes mellitus control with effective oral antidiabetics or insulin, and achievement of target blood pressure goals with sufficient antihypertensive drugs.
For the treatment of LMCA disease, there are usually three options, which include optimal medical therapy, percutaneous revascularization or surgical revascularization, either off-pump or on-pump. For various cases, hybrid methods may also be applied according to the health condition of the patient or the preference of the clinician.
For many decades, CABG/open-heart surgery has been recognized as the normal revascularization process for LMCA disease. However, advancement in the medical sciences and several randomized controlled trials have demonstrated positive outcomes for angioplasty i.e. drug-eluting stent (DES) PCI relative to CABG.
IVUS (Intravascular Ultrasound) is a modality of intracoronary imaging that enables the anatomical representation of the lumen of the vessel and characterizes plaques. A 360° sagittal scan of the vessel from the lumen through the media to the wall of the vessel is given. Compared to coronary angiography, IVUS provides additional information such as minimum and maximum diameters, cross-sectional area and plaque area.
Fractional flow reserve (FFR) is the ratio determined during maximal hyperemia between distal coronary pressure and aortic pressure. It is a relatively simple method that gives a representation via a stenotic artery of the fraction of normal blood flow.
Optical Coherence Tomography (OCT) is a non-invasive imaging technology used to produce cross-sectional images of the retina with a high resolution. In order to assist in the early detection and diagnosis of retinal diseases and disorders, the layers inside the retina can be distinguished and retinal thickness can be measured. For the diagnosis and treatment of most retinal disorders, OCT examination has become a standard of care. In order to calculate retinal thickness, OCT uses rays of light. In this procedure, no radiation or X-rays are used, and an OCT scan does not hurt and is not painful.
Left main or left main coronary artery (LMCA) is one of the major coronary arteries, which supplies blood to the left territory of the heart. Left main disease or LMCA lesion refers to the block or occlusion or lesion formation in the LMCA.
The left main coronary artery supplies blood to the left side of the heart muscle (the left ventricle and left atrium). The left main coronary splits into branches: LCX ( left circumflex artery) and LAD (left anterior descending artery).
A left coronary artery block can reduce your functionality, and in some cases can cause a heart attack. Crushing pressure in your chest and pain in your shoulder or arm, sometimes associated with shortness of breath and sweating are the classic symptoms of a heart attack.
Patients with advanced coronary artery disease, such as LMCA block are candidates for the procedure called left main stenting. This procedure involves placing a time-release medication-coated metal stent into the artery for opening the blockage.