By Medicover Hospitals / 16 Jan 2021
Home | Medicine | Repaglinide

Repaglinide, which was invented in 1983, is an antidiabetic drug in the family of medicines known as meglitinide. Repaglinide is an oral drug used by type 2 diabetes mellitus in addition to diet and exercise for blood sugar management.

Tablet strengths are available in

  • -0.5mg
  • -1mg
  • -2mg
  1. Repaglinide Uses
  2. Repaglinide side effects
  3. Precautions
  4. Repaglinide Dosage
  5. Repaglinide Storage
  6. Repaglinide vs Metformin
  7. Frequently Asked Questions
  8. Citations

Repaglinide Uses

Repaglinide, combined with a healthy diet and exercise regimen, is used alone or with other drugs to regulate elevated blood sugar. It is used in persons that have type 2 diabetes. High blood sugar management helps you to prevent kidney damage, nerve disorders, blindness, limb loss, and issues with sexual function. Proper diabetes management can also decrease the risk of getting a heart attack or stroke. It acts to generate more insulin by stimulating the body. Insulin is a natural product that enables sugar from the diet to be properly used by the body.

How to use

  • Before you start using repaglinide, and each time you get a refill, read the Patient Information given on the Leaflet. Consult your physician or pharmacist if you have any questions/confusion.
  • Take this medicine by mouth, as instructed by your doctor, within 30 minutes before each meal, usually 2-4 times daily, depending on the number of meals. If you miss the meal, or if your blood sugar is poor, do not take a dose of medicine.
  • The dosage is totally dependent on your medical condition, medicational reaction, and other medicines that you may be taking. Tell your doctor and pharmacist about all the drugs you use (including prescription, over-the-counter)
  • If you are moving from another diabetes medicine (such as chlorpropamide) to repaglinide, follow the instructions carefully provided by your doctor to quit using the old medicine and to start using this drug.
  • To get the most benefits from it, use this drug regularly as instructed by your doctor. Follow your doctor's recommended opioid treatment plan, meal plan, and workout routine carefully.
  • Regularly monitor your blood sugar according to your doctor's instructions. Keep an eye on the observations, and share them with your doctor. In order to assess the right dosage, this is very important. If your blood sugar measurements are too high or too low, inform your doctor. The change will have to be done for your recovery plan.

Repaglinide Side Effects:

  • Shakiness
  • Dizziness or lightheadedness
  • Sweating
  • Nervousness or irritability
  • Sudden changes in behavior or mood
  • Headache
  • Numbness or tingling around the mouth
  • Weakness
  • Pale skin
  • Hunger
  • Clumsy or jerky movements
  • There may be weight gain, diarrhea, and joint pain. If any of these symptoms persist, immediately inform your physician or pharmacist and seek medical advice.
  • Know that this drug has been prescribed by your doctor because he or she has decided that the value is greater than the risk of side effects. There are no significant side effects for many people who are taking this drug.
  • Repaglinide can cause low blood sugar (hypoglycemia), especially if other diabetes medicines are used. It can also contribute to low blood sugar by drinking large amounts of alcohol, not having enough calories from food, or doing unusually intense exercise.
  • Chills, cold sweat, dizziness, drowsiness, trembling, rapid pulse, fatigue, headache, fainting, hand or foot tingling, or hunger can be symptoms. Carrying glucose pills or gel to treat low blood sugar is a healthy practice. If you do not have these reliable sources of glucose, consume a fast source of sugar, such as table sugar, honey, candy, or drink a glass of fruit juice or non-diet soda, to increase your blood sugar quickly. To find out what you can do if you miss a meal, consult with your doctor or pharmacist.
  • Thirst, increased urination, nausea, drowsiness, flushing, quick breathing, and fruity breath odor are signs of elevated blood sugar (hyperglycemia). If these signs continue your doctor may need to change or adjust some doses
  • It is very unusual to experience a very severe/serious allergic reaction to this drug. However, if you experience any of the following signs of a serious allergic reaction, seek immediate medical attention: rash, itching/swelling (especially of the face/tongue/throat), extreme dizziness, difficulty breathing.


  • Inform your doctor or pharmacist whether you are allergic to repaglinide or if you have any other reactions before taking repaglinide. There may be many inactive ingredients present in this substance that may cause allergic reactions or other problems. Talk to your pharmacist for more details/information/queries.
  • Tell your doctor or pharmacist your medical history prior to taking this drug, including kidney disease, liver disease.
  • Because of extremely low or high blood sugar, you can experience blurred vision, dizziness, or drowsiness. Unless you are confident that you can conduct such activities safely, do not drive, use machinery, or do any operation that needs alertness or clear vision.
  • Limit alcohol when taking this drug since low blood sugar will increase the risk of developing it.
  • It can be harder to regulate your blood sugar during periods of stress, such as fever, infection, injury, or surgery. Consult your doctor because a change in your treatment plan, drugs, or blood sugar tests could be appropriate for elevated stress.
  • This drug should only be used during pregnancy when it is specifically needed. Pregnancy can cause diabetes or make it worse. Discuss a strategy for controlling your blood sugar during pregnancy with your doctor. During your pregnancy, your doctor may change your treatment for diabetes. Discuss the dangers and benefits of various treatments (such as nutrition, exercise, etc.)
  • It is unknown if this drug passes into breast milk or not. Because of some possible risk to the infants, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.


  • Drug interactions might affect or also can change the effect of working on your drugs or increase the risk of very serious side effects. Keep a list of all medicational drugs you have been using and share it with your doctor. Without your doctor's permission, do not start, or adjust the dosage of any medication.
  • NPH insulin is a substance that can interfere with this drug.
  • The removal of repaglinide from your body can be impaired by other drugs, which may influence how repaglinide functions. Examples include clopidogrel, gemfibrozil, trimethoprim, antifungal azole (such as itraconazole), antibiotice macrolide, trimethoprim
  • Your blood sugar can be influenced by many medications, making it harder to regulate. Examples include, among others, corticosteroids (such as prednisone), psychiatric drugs (such as olanzapine), antibiotics with a fluoroquinolone (such as ciprofloxacin). As instructed, check your blood sugar levels regularly and share the results with your doctor. Tell your doctor right away if you experience high or low blood sugar symptoms. (See also Section on Side Effects.) Your doctor can need to change your prescription, exercise schedule, or diet for diabetes.
  • Beta-blocker drugs (such as metoprolol; propranolol; eye drops of glaucoma such as timolol) can avoid the fast pulse rate that you will normally feel when your blood sugar drops.
  • Carefully check the labels on all of your medications (such as cough-and-cold products). Sugar or alcohol can be found in certain items and may influence blood sugar. Ask your physician or pharmacist regarding the proper use of these drugs.
  • The outcomes of urine tests for sugar or ketones may be impaired by other drugs.


Call a poison control center immediately if you or someone has overdosed and are having some severe signs such as passing out or difficulty breathing. Overdose signs can include extremely quick heart rate, changes in vision, unexplained heavy sweating, restlessness, fainting, seizures.


  • - Do not share with anyone this drug.
  • - To learn more about how to treat your diabetes with drugs, diet, exercise, and routine medical examinations, join a diabetes education class. Learn about the effects of high and low blood sugar and how low blood sugar can be treated.
  • - As instructed, check your blood levels sugar regularly and share the results with your doctor. Laboratory or medical examinations (such as tests for kidney function, blood glucose fasting

Missed Dose:

If you miss a dose or forget to take any dosage of this drug, skip it don’t take it. With the next meal, take the next dose. To catch up, never try to double the dose.


Store it away from light and moisture at room temperature. Do not store your drugs in the bathroom/washroom. Hold kids and pets away from all drugs. Unless required to do so, do not flush drugs down the toilet or into the drainage system. When it is expired or no longer needed, properly discard this drug. Consult your nearest waste collection company or pharmacist.

Repaglinide vs Metformin:

Repaglinide Metformin
Repaglinide belongs to a class of medications known as meglitinides Metformin, marketed under the trade name Glucophage
It is used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus This drug is used as the first-line medication for the treatment of type 2 diabetes
It is also used in lowering blood glucose drug It is also used for the treatment of polycystic ovary syndrome(PCOS )
It might cause you some changes in weight It is not associated with weight gain
Oral medication It is taken by mouth.

Frequently Asked Questions:

Repaglinide (also known as PRANDIN) is an oral blood-glucose-lowering drug of the glinide class.
Repaglinide comes in the forms of a tablet to be taken by mouth. The tablets are taken before taking meals, or any time from 30 minutes before a meal to just before the meal. If you are skipping the meal, you need to skip the dose of repaglinide also.
Chills, cold sweat, dizziness, drowsiness, trembling, rapid pulse, fatigue, headache, fainting, hand or foot tingling, or hunger can be some of the side effects
This diabetes medication is a combination of two drugs (repaglinide and metformin). It is taken along with a proper diet and exercise schedule to control high blood sugar in patients with type 2 diabetes. Repaglinide works by stimulating the release of natural insulin in your body.
Metformin and repaglinide are a mixture of two medicinal drugs for oral diabetes that help regulate blood sugar levels. Along with diet and exercise, metformin and repaglinide are used to promote blood sugar regulation in adults with type 2 diabetes.


  • Repaglinide,
  • Repaglinide Dosage,